Interprovincial Lottery Corporation Rules and Regulations. Barcelona clinic liver cancer (BCLC) staging uses a set of criteria to guide the management of patients with hepatocellular carcinoma (HCC). 8. 2. However, the tumour burden may be quite heterogeneous in this stage, and prognosis is also influenced by the degree of liver. The point spread in hockey odds is often referred to as the puck line. PROPS final results include OT but not shootouts. 8 yards, making his 2. Keno & Keno Bonus. 58 total); South Carolina was +110 underdog. The Barcelona Clinic Liver Cancer (BCLC) system is the most commonly used staging system for hepatocellular carcinoma (HCC) in Western countries. 5-point favorite has to win by more than 5. Spread Moneyline Total Points; 49ers. Primary liver cancer is a challenging global health concern with an estimated more than a million persons to be affected annually by the year 2025. In order for a comparable potential winning payout to a player, more money must be risked to bet the favoured team; less money on the weaker team. The right lung has three lobes, and the left lung has two. You have faqs? We have claims!The BCLC staging system was proposed and has been validated by several groups in the United States and Europe to offer the best means of stage classification and treatment guidance for HCC. A total, also known as an over/under, is a bet on the number of points both teams will combine to score in a game. Eight years later, in July 2019, the FDA requested that Allergan, the manufacturer of a type of textured implant, recall. Interprovincial Lottery Corporation Rules and Regulations. BCLC has sponsored a variety of products and gift cards from local businesses, including Native Shoes, Rocky Point Ice Cream, and Cartems Donuts and made them available on the Spread the Local Love campaign page. Moneylines; Totals. The betting line will almost always be different than -110, as 1. “Total O/U” shows the record. To help, BCLC is launching Spread the Local Love, an online fundraising campaign, running from February 1 to 15. C were temporarily closed in. Lottery Corporation has finally given up a decade-long fight to keep a secret. Compared to the 2018 version where LT was (only) recommended in multifocal ≤ 3 cm HCCs, three arrows are now directed toward LT, one from each of the following: small multifocal HCCs, a subgroup of BCLC B patients, in case of successful downstaging by TACE or TARE. 95 in payouts for a total of $227. 5) cover the spread at home versus the Saints. Point Spreads. The British Columbia Lottery Corporation is a Canadian Crown corporation offering a range of gambling (AKA gaming) products including lottery tickets, casinos and legal online gambling. C. This means there is a single tumour of any size, or up to 3 tumours all less than 3 cm. On Wednesday afternoon, the line inched down to Wisconsin -6. Step 1: Visit a participating retailer or access the BCLC PlayNow website. Top Goal Scorer/ Point Scorer bets Top goal scorer/point scorer in a competition will be Settled in accordance with the Dead Heat Reduction Rule if players finish on the same number of goals/points scored, regardless ofBCLC’s Sports Action is a great product, but not the only option for sports bettors in the province. Point Spread: Pick the outcome of two to 12 games with a point spread factored in. Kamloops, BC V2C 6H2. Were observed significant differences in the mean survival rates among B1, B2, B3 and B4 patients. Here are the steps to follow: Step 1: Visit a participating retailer or access the BCLC PlayNow website. OddsChecker is the most knowledgeable and helpful place for sports betting online. Select the numbers yourself or choose a Quick Pick. 5-point. As well known, the intermediate stage is defined as multifocal HCC (beyond BCLC-A criteria; see Figure 1) with preserved liver function, no cancer-related symptoms, and no vascular invasion or extrahepatic spread. 45 for a total payout of $95. POINT SPREAD: Visit (-0. 5. Examining individual patient assessment for using TACE (transarterial. 4. 9∼4. Although the BCLC staging system has been endorsed by both the European Association for the Study of the Liver (EASL)4 and the American Association for the Study of Liver Diseases (AASLD),5 several investigators have advocated for extending the resection criteria to select patients with BCLC-B or even BCLC-C HCC;9,10, − 11 For example, Wada and colleagues reported a 5-year overall survival. Find out all of the great Lotto 6/49 and Extra prizes available to be won and the odds of winning them. M. Surveillance (or screening) for HCC is recommended for patients with cirrhosis and subgroups of patients with chronic hepatitis B using ultrasound and a serum biomarker, alpha-fetoprotein, every 6 months. Decide how many consecutive plays (up to 99) Set your wager - $1, $2, $5 or $10 per draw. March 3, 2021. Meaningful and accurate information about games, rules of play and general odds of winning (detailed information on the odds of winning on. Indianapolis Colts South Point and Wynn are two of the last sports books on Earth with the half-point hook still attached on the Texans to make this a must-play. 22. Odds Shark Staff Last Updated: Jun 26, 2023 12:51 PM ET. T: 250-828-5500. Background and aims: The Barcelona Clinic Liver Cancer (BCLC) staging system is the algorithm most widely used to manage patients with hepatocellular carcinoma (HCC). org. 5) covers by losing by fewer than 25. Check out these testimonials about our exceptional church loan services. 1. Purpose: There is a lack of consensus on the surveillance strategy for Barcelona Clinic liver cancer (BCLC) stage B hepatocellular carcinoma (HCC) patients with complete remission (CR). 5, and. Spread betting. It’s also often labelled as 1×2 or 3-way betting. Pickswise is the best place to get free expert NFL picks. The Barcelona Clinic Liver Cancer (BCLC) system is the most used staging system for HCC . The Packers are 16-7 ATS as. Using an online sportsbook simplifies the betting process. A significant increase is also evident among men over 60 [4]. Football Betting Tips & Predictions 09. It stratifies prognosis by integrating albumin-bilirubin score and alpha fetoprotein for additional granularity, particularly for BCLC stage B. Final results include any injury/stoppage time. The TNM classification for staging of hepatocellular carcinoma is provided below. The median OS of HKLC stage II (IIa and IIb), III (IIIa and IIIb), and IV (IVa and IVb) patients was in 31. Dallas Cowboys at Carolina Panthers: 42. We performed a real-world, retrospective analysis of the surveillance strategy for BCLC stage B HCC patients after radical therapy with CR to. Barcelona clinic liver cancer (BCLC) staging uses a set of criteria to guide the management of patients with hepatocellular carcinoma (HCC). Based on these results, treatment of BCLC-C patients should be performed discretely and with caution even if OR is obtained at first radiological evaluation. A winning bettor will win $100 for every $110 bet. With 19 casinos spread over a large 700 mile geographical area that spans two times zones, the Casino Incident Reporting and Risk Management System needed to have the capability of linking multiple sites to the corporation via a central server in real time, while reporting back to BCLC all activity on the system, with BCLC controlling all data. If you have enrolled in BCLC's Voluntary Self-Exclusion/Game Break program please refrain from taking this survey. tumor size. The treatment options for this stage are limited, and sorafenib monotherapy is the standard of care; however, the 2% to 3. BCLC stage 0 is a localized circumscribed tumor <. A higher number, such as stage IV, means cancer has spread more. (Getty Images) Point spread betting is a bet on the difference in the score between teams (or players) in a specific game or event. It's two-way action on the spread, with 56% of bets/59% of dollars on the road favorite Badgers. It also says one side of the spread hits well. (c) “OVER/UNDER” means whether based on the Result the Aggregate Score will be over or under BCLC’s pre-set line for that Sports Action Event. | Find, read and cite all the research. Accordingly, the BCLC staging system is viewed as being necessary for clinical trials and the reporting of clinical data. It also provides recommendations of treatment and/or management for each stage of disease. Lotto 6/49 Game Conditions in effect of Sept 14 2022. A PRO•LINE TIE occurs when the fight ends in a draw. rookies. 5) Home (+0. Currently, sorafenib is the only recommended treatment for patients with BCLC-C and outcomes remain suboptimal. C. Opening point spread: Eagles -6. If you reach Triple Diamond status, you’ll get twice as many Accelerator Bonus Points on every point you earn. 6% (n = 264) presented in BCLC stage A, 47. V2C 1E2. To calculate “+” odds, divide the odds by 100 and multiply that product by the amount of the wager. BC 50/50. In sports betting, the point spread is a number set by oddsmakers to level the playing field between two teams and drive betting action on both sides. It is a primary liver malignancy that is. O. GAMETIME/LOCATION: Rutgers Scarlet Knights (4-5, 1-5 in the Big Ten) at Indiana Hoosiers (2-7, 0. The official lottery app for the British Columbia Lottery Corporation (BCLC). Portal vein invasion (PVI) and extrahepatic spread (ES) are two tumor-related factors that define advanced stage in the Barcelona Clinic Liver Cancer (BCLC) staging system (BCLC stage C), and the recommended first line therapy in this stage is sorafenib. 1 The prognosis for HCC patients is determined by tumor status, liver function reserve, general health, and treatment efficacy. is multinodular and unresectable, advanced stage (C) is the presence of portal invasion or extrahepatic spread, and terminal stage (D) is a. BCLC FAQs. Once the point spread is set, you can bet on either side of it. It is typically diagnosed late in the course of these diseases, and the median survival following diagnosis ranges from approximately 6 to 20. It consists of three business units, Lottery, Casino and eGaming; and five support divisions, Human. We aimed to investigate the prognostic value of BDI and the stage of BDI in different staging systems. Manage Your Play Encore Rewards Promotions Winners . consumerservices@bclc. 8%: Proline Odds: 1. Survival analyses were performed using the Kaplan-Meier analysis, and the statistical differences between the TACE and sorafenib groups were examined by the log-rank test. San Francisco 49ers at Seattle Seahawks: 42. Overall approximate odds to win a prize on a $3 Super Crossword are 1: 3. The Business Connections Learning Community (BCLC) is a living and learning community available to UConn Business students on the Storrs and Stamford campuses. Localized (cancer is confined to where it started) Regional (cancer has spread to nearby lymph nodes) Distant (cancer has spread to distant body parts) The five-year relative survival rates for liver cancer according to SEER stages are: Localized: 35. In 2011, the Food and Drug Administration (FDA) identified a possible link between textured breast implants and a rare form of lymphoma known as breast-implant-associated anaplastic large-cell lymphoma, or BIA-ALCL. Prognosis. 7%-21. The 2022 WCLC Annual Report showed sales revenue of just over $88 million for Sport Select in 2022, up from $65. for Oddset 2-Outcome: the final outcome of a Sports Action Event listed on the Menu that constitutes either a home Win or a Visitor Win, including extra play, as determined by the applicable Governing Body and verified by BCLC, Point Spread Betting Guide; Prop Betting Guide;. Several potentially. The point spread is one of the most popular sports betting options when it comes to betting on college football and the NFL. ersial. In the NHL, the puck line is almost always set at 1. rookies New to Sports. Fibrous expansion of portal areas with marked bridging as well as portal-central. 6460 media[email protected]) covers by winning by more than 2. Contests & Promotions. Background and Aims Treatment of patients with Barcelona Clinic Liver Cancer Stage B hepatocellular carcinoma (BCLC-B HCC) is controversial. $150 Match Deposit Offer . As part of the campaign, BCLC sponsored a number of items and gift cards from local businesses. Surveillance. stage B: immediate. Therefore, the BCLC stage may be regarded as a useful predictor of outcomes in clinical practice because it includes microvascular invasion and the underlying conditions of patients. Although each person’s cancer experience is unique, cancers with similar stages tend to have a similar outlook and are often treated in much the same way. BCLC. . Every Tuesday and Friday night at 7:30pm PT. For example, if the New England Patriots were favored to win against the New York Jets by 2. It’s just like in basketball or any other sport, where a team would be favored by -9. Introduction. C. radiologic tumor extent. Building on the success of the award winning campaign, Spread the Local Love, BCLC is launching Love Local BC . The British Columbia Lottery Corporation (BCLC) oversees sports betting in the province and has permitted parlay bets since 1985. The number that expresses probability of an event to occur, as offered by BCLC. Opening point spread: Colorado -23 Opening moneyline: Colorado -2500/Colorado State +1100 Opening total: Over/Under 59. fixed match correct scores today. Citation, DOI, disclosures and article data. BCLC staging system is based on four different variables with qualitative or quantitative assessment: child score (child A, child B, and child C); performance status (0–4); nodule size; and nodule. Learning what a point spread is, how to read a point spread is, and how to formulate a gameplan on point spread picks increases your chances of success and profit. How to Play Over / Under Think the game is going to be an offensive. Spread betting is a bet on the margin of victory in a game. Poker Lotto. Similarly, -3. INTRODUCTION. M. 1. Results: Out of 124 patients, 47. For patients with BCLC stage C HCC,. Jackpots of $10-$70 million. You can also visit the BCLC offices in Kamloops or Vancouver, call BCLC's Consumer Services at 1-866-815-0222, or visit. Staging systems of hepatocellular carcinoma: A review. RC. For $1 per play, you’ll receive 6 numbers from 1 to 49. Tennessee (N) 133. College Basketball Point Spreads. Poker Lotto. 2 More than 80% of HCC. . If you or someone you know has a problem with gambling, please call the Problem Gambling Helpline at 1-888-795. Whether you pick the underdog or the favourite, the point spread creates an even playing field making every game closer. Campbell vs. When betting on the underdog at +160, you would bet $100 to win $160 (if the underdog wins). Free NFL Point Spread Picks. Oddset Before you can play the game, you need to learn the game. Call 1-800-327-5050 or visit gamblinghelplinema. 88: 2. 5) Win Probability: 53. On the other hand, Baltimore is just 2-2 against the spread as a favorite. BCLC is proud to announce a new resource dedicated to supporting players in Williams Lake with healthy-play habits, and referring those experiencing challenges with their gambling to the support resources they need. The. There have been major advances in the armamentarium for hepatocellular carcinoma (HCC) since the last official update of the Barcelona Clinic Liver Cancer prognosis and treatment strategy published in 2018. Pull Tabs. Our NBA predictions will give you the best insight on how to. Portal vein invasion (PVI) and extrahepatic spread (ES) are two tumor-related factors that define advanced stage in the Barcelona Clinic Liver Cancer (BCLC) staging system (BCLC stage C), and the recommended first line therapy in this stage is sorafenib. 4 A. The BC/49 $2 million top prize will be shared if there is more than one winning selection. 2∼33. Prizes up to $9,999. BC 50/50. However, the tumour burden may be quite heterogeneous in this stage, and prognosis is also influenced by the degree of liver. The original BCLC staging system published in 1999 classified large solitary HCC as Stage A; 4 but the cut-off size of 5cm was later introduced in the revised versions, which then recommended large solitary HCC to be classified either as Stage A or B. In spread betting, the underdog can win or lose by less than specified points. 4. BCLC reserves the right to limit the number of picks in a parlay, in its sole discretion. “ATS” is a representation of the record based on wagers against the spread. Knowing several games at a time and making individual betting prThe estimated survival time for HCC patients with BCLC stage B is more than 2. Scratch & Win. 2. Step Six Use the Purolator PIN number to track your shipment at If you require additional information regarding Buybacks, contact the BCLC Lottery Support Hotline at: 1-800-667-1649. BCLC. Selective internal radiation therapy (SIRT) offers hope, although which patients benefit over standard approaches remains unclear. 43. S. 225. FanDuel Sportsbook offers college basketball odds, including spreads, moneylines, over/under point totals, and prop bets for every college basketball game from the regular season games through the NCAA Tournament in March. Poor response rates further hamper outcomes for those that are. To this point, the original BCLC system was updated in 2011 to designate solitary large HCC (≥ 5 cm) as BCLC-A rather than BCLC-B,27 acknowledging that resection, rather than other locoregional therapies,. Breast cancer liver metastasis (BCLM) is associated with poor prognoses, with the median survival time being 2 to 3 years. GameSense is here to help keep gambling a safe, fun source of entertainment. GameSense is here to help keep gambling a safe, fun source of entertainment. P. Many staging systems have been used to provide a clinical classification in patients with HCC and as mentioned earlier the best system would be that take in to account the tumor status (defined by tumor size and number, presence of vascular invasion and extrahepatic spread), liver function (defined either by the Child-Pugh’s class or individually. BCLC stage B group patients were distributed from HKLC stage I to III, and BCLC stage C group patients were distributed from HKLC stage II to V. Background: Although the Barcelona Clinic Liver Cancer (BCLC) staging system has been largely adopted in clinical practice, recent studies have emphasized the need for further refinement and subclassification of this system. The BCLC staging system has been externally validated in different clinical settings. If you or someone you know has a problem with gambling, please call the Problem Gambling Helpline at 1-888-795-6111. The Barcelona Clinic Liver Cancer (BCLC) staging system has been recommended to be the prognostic model and also the allocating tool of primary anti-cancer treatment by major academic societies for liver diseases [1, 2]. Run line favorites are posted at -1. 14 to 0. The Gold Ball Jackpot is here. ” In the case of a push, all bets are returned to the bettor. We believe the Bible to be the inspired, infallible and authoritative word of God. 68: Correct Odds: 1. Point Spreads. Tumor intrinsic subtype directs preferential metastasis to specific organs, with HER2-enriched tumors demonstrating the highest rates of metastasis to the liver, though all subtypes can grow in the liver. Read the latest Week 12 NFL odds, betting lines, spreads, totals & more to make the top picks throughout the 2023 NFL season. Extra Game Conditions and Prize Structure. The second novelty in this update is the recognition of liver transplantation (LT) as one of the main objectives. A flowchart of the BCLC guidelines is shown in Figure 8 [19]. Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. The Barcelona Clinic Liver Cancer (BCLC) staging system [] is widely applied for tumor characterization and to. Chances Signal Point is one of sev. College basketball point spread betting. Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. Understand the key concepts that influence the outcome every time you gamble. Instant Ticket Game Conditions. It contains 5 stages: very early, early, intermediate,. No claim or right of action exists against BCLC with respect to any Ticket or Prize, unless the claimant satisfies BCLC that the claimant is a winner and that the conditions of Section 24 of these Sports Betting Rules have been fulfilled. gov means it's official. 5 vs. BC/49 & Extra. The point spread is the expected final score difference between two teams. Davidson vs. Contests & Promotions. Learn more ». and/or vascular invasion and/or extrahepatic spread were present. In Ontario, the games are called Proline while they are. The site initially went live in 2004, but it wasn’t until 2010 that it officially became the first casino. (f) “Odds” means the odds for a Sports Action Event as determined by BCLC (g) “Result” means: I. NCAA basketball odds will be released daily, and these betting odds will be refreshed up to the minute on our. Survival analyses were performed using the Kaplan-Meier analysis, and statistical differences between the TACE and sorafenib groups. Play BC lottery games online. Because it can take years for cancer cells to travel from the capsule to other areas of the body, the amount of time it takes Bia-ALCL to spread is unpredictable. 13 A winning bettor will win $100 for every $110 bet. 95 including the original $100 risked across the two separate bets. Top Week 6 NFL predictions. Gonzaga covers by winning by three points or more, such as 75-69. BCLC has continued to take action to address the risk of money laundering. Transarterial radioembolization (TARE) has recently entered at the left. Select your games and see your potential winnings. A Point Spread bet helps even the odds of any particular sporting event by subtracting points from the favoured competitor and subsequently adding the same amount of points to the weaker competitor. 3% response rate and modest overall survival (OS) benefit of 2 to 3 months, raises the. As well known, the intermediate stage is defined as multifocal HCC (beyond BCLC-A criteria; see Figure 1) with preserved liver function, no cancer-related symptoms, and no vascular invasion or extrahepatic spread. The. Each pick is meticulously researched by an experienced NFL handicapper, using our own data, custom-built models, and analytical methods. A + means that team is bet is an underdog. Choose the one that best suits you. Many staging systems have been used to provide a clinical classification in patients with HCC and as mentioned earlier the best system would be that take in to account the tumor status (defined by tumor size and number, presence of vascular invasion and extrahepatic spread), liver function (defined. A point spread bets sees the sportsbook add/subtract a number of points to one team’s final score in a matchup between two teams. 0001). 2 months) or. An optimal staging system needs to incorporate the 1) severity of underlying disease, and 2) size and degree of spread of tumor. Extra Game Conditions and Prize Structure. Yes, it is legal to bet on sports in British Columbia. If there are more than six 5/6+ Bonus winners ($75,000 prize), each winner will share in. How to Play. Hepatocellular carcinoma (HCC) is an aggressive tumor that often occurs in the setting of chronic liver disease and cirrhosis. 3 percent. McNeese St vs. After Settlement of a Pool and corresponding payment of the Prize Pool by BCLC, any subsequent corrections or amendments by the governing body to the result will not be applicable. The Barcelona Clinic Liver Cancer (BCLC) staging. BCLC FAQs. (x) Draw 4. OR odds ratio, CI confidence interval, BCLC Barcelona Clinic Liver Cancer, ALBI albumin-bilirubin, MELD model for end-stage liver disease. There are different staging systems doctors can use for liver cancer. Thirty-seven patients without vascular invasion or extrahepatic spread who were classified as BCLC C because of compromised performance status (ECOG 1–2) received HCC therapy according to the number and size of tumors as follows: liver transplant (n=2), resection for a single nodule without portal hypertension (n=5), RFA or PEI (n=9), or TACE. We performed a real-world, retrospective analysis of the surveillance strategy for BCLC stage B HCC patients after radical therapy with CR to. Since its inception in 1999, it clarifies the decision-making process regarding the. Register, whereas sorafenib patients were obtained from the ITA. Betting on the opening slate of NFL. 3 months), presence of extrahepatic spread (11. We are dedicated to bringing you the best betting picks, odds, and overall sports analysis that you will find anywhere. Finn, MD: Can you give us a brief overview of the BCLC [Barcelona Clinic Liver Cancer] staging system? There’s early stage, which is 0; there is A, B, C, and then there’s D stage. 5 underdog can lose by five or fewer, or win outright. 6% were in BCLC-B and 52. They won back-to-back Grey Cups in 2019 and 2021 (2020 was wiped out by the pandemic) and fell one point short of a three-peat last year when Toronto upset them 24-23. , which distributed it in many ways to benefit British Columbians: $ 28. View the NFL Daily Lines on ESPN. 75. Betting on football point spreads is the most popular way of laying NFL and NBA bets. 5 points, the bettor can choose one. Covers' NCAAF free picks & predictions will help you make smarter betting decisions throughout the NCAAF season. Spread bets change because sportsbooks shift odds for. Keno & Keno Bonus. Point spreads are fairly common in the sports betting industry and well known around the world. 94 total); Chargers were +105 underdogs (bet $10 to win $20. How to Play. You feel well and are active (PS 0), and your liver is working well (Child. Introduction. Pacific Hold'Em Poker. The Lotto! Certification Program is part of BCLC's commitment to provide you with the information and tools you will need to sell and validate lottery games with integrity. The top Extra prize is $500,000. Pacific Hold'Em Poker. Overview. 0 months, respectively [ 25 ]. Step 2: Browse the Sports Action menu to find the games you wish to bet on. Detroit is a 5. Games. 46 total); Packers were +114 underdogs (bet $10 to win $21. 5,21,22 Since the original publication of the BCLC algorithm in 1999, 23 its parameters have been used in most. Survival analyses were performed using the Kaplan-Meier analysis, and the statistical differences between the TACE and sorafenib groups were examined by the log-rank test. BCLC stage C (advanced HCC with vascular invasion or extrahepatic metastasis, Child-Pugh class A or B, ECOG PS 1-2). You've got two options for how you'll get there. BCLC aims to categorize patients into five stages with different prognoses and to allocate treatment according to these stages based on the best possible contemporary evidence. The Rams were installed as a 4. 1 Liver transplantation and hepatectomy are both viable treatment strategies for treating HCC. It evens the playing field for bettors, giving similar odds to both the favorite and underdog. Boston U. Gilgeous-Alexander leads Oklahoma City against Philadelphia after 40-point performance. 5, 2, 5, 7, or 10 times. Tools and resources to help you if gambling no longer feels like a game. Pawlik, MD, PhD, MPH, MTS, MBA1 1Department of Surgery, The Ohio State University Wexner Medical Center, James Comprehensive Cancer Center, Columbus, OH; 2Tufts. Approximately 80%. The treatment algorithm suggested by the BCLC classification homogenized the surgery group and in turn increased performance of outcome predictability of the BCLC classification. BCLC staging and treatment strategy in 2022. If you wagered $100, you would. Hepatic resection has the highest local controllability that results in long-term survival for hepatocellular carcinoma (HCC). 09 – your original $10 comes back along with your $9. Point spread: Raiders (-1. The treatment options for the. BC/49 Game Conditions and Prize Structure. NFL Week 12 over/unders (point totals): Green Bay Packers at Detroit Lions: 46. Hepatocellular carcinoma (HCC) is one of the major complications of cirrhosis and chronic hepatitis B. Let's take the 2022 Super Bowl example: Rams -4. From February 1 to 15, 2021, B. Sorafenib treatment is the only available option for well-moderate compensated cirrhotic patients with Barcelona Clinic Liver Cancer stage B (BCLC-C) advanced hepatocellular carcinoma (HCC) stage or with BCLC-B intermediate HCC with tumour progressing after ineffective loco-regional therapies [1,2,3,4,5,6,7,8,9].